It takes a pair to beat the odds.
Adam Lerner (Joseph Gordon-Levitt) has a pretty great life—with a talented, sexy artist girlfriend and a great job, the 27-year-old seems to have it all. But when Adam begins to suffer with agonizing back pain, he discovers that he has a rare and possibly fatal form of cancer.
With a massive, malignant tumor growing along his spinal column, his life changes in a heartbeat. Coffee shops give way to chemotherapy clinics, art openings to counseling sessions and plans for the future to strategies for survival.
His best friend, Kyle (Seth Rogen), uses Adam's condition to lure girls into sympathy sex, his overbearing mother (Anjelica Huston) loses sight of him in her own fears, his otherwise-occupied girlfriend, Rachael (Bryce Dallas Howard) tries to distract herself an increasingly frantic social life, and Katherine (Anna Kendrick), the young therapist assigned to his case, struggles to keep up with the needs of her third client ever.